LINC-ROR

Chr 18

long independently transcribed non-coding RNA, regulator of reprogramming

Also known as: ROR, lincRNA-RoR, lincRNA-ST8SIA3

NCBI Gene: 100885779 ENSG00000258609 OMIM: 615173

This gene produces a long non-coding RNA that regulates pluripotent stem cell reprogramming by acting as a molecular sponge for microRNAs that control key stem cell transcription factors including POU5F1, NANOG, and SOX2, and suppresses p53 induction after DNA damage. No pediatric neurological diseases have been definitively associated with mutations in this gene based on the available information.

OMIM ResearchSummary from RefSeq

This gene produces a long non-coding RNA that regulates the reprogramming of pluripotent stem cells. This RNA suppresses induction of tumor protein p53 after DNA damage. It is thought to act as a sponge for microRNAs that regulate stem cell factors POU class 5 homeobox 1, Nanog, and SRY-box 2. This RNA may also have a extracellular role in modulating response to hypoxia in hepatocellular cancer cells. Expression of this transcript is associated with tumor progression and epithelial to mesenchymal transition and metastasis. [provided by RefSeq, Dec 2017]

OMIM ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

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LOEUF

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Mechanism