LINC-PINT

Chr 7

long intergenic non-protein coding RNA, p53 induced transcript

Also known as: LincRNA-Pint, MKLN1-AS1, PINT, PINT87aa, TISPL

NCBI Gene: 378805ENSG00000231721UniProt: A0A455ZAR2

Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

15
ClinVar variants
9
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— LINC-PINT
📋
ClinVar Variants
9 Pathogenic / Likely Pathogenic· 1 VUS of 15 total submissions
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

15 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic9
VUS1
Likely Benign3
Benign2
9
Pathogenic
1
VUS
3
Likely Benign
2
Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
0
0
9
0
9
Likely Pathogenic
0
0
0
0
0
VUS
0
0
1
0
1
Likely Benign
0
0
3
0
3
Benign
0
0
2
0
2
Total0015015

LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

LINC-PINT · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype

OMIM

No OMIM entries found.

Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
PINTology: A short history of the lncRNA LINC-PINT in different diseases.
Bukhari I et al.·Wiley Interdiscip Rev RNA
2022Review
lncRNA LINC-PINT controls lymphatic function and inflammatory profile in lymphedema.
Laugero N et al.·Sci Adv
2025
Long non-coding RNA LINC-PINT as a novel prognostic biomarker in human cancer: a meta-analysis and machine learning.
Lin J et al.·Sci Rep
2024Meta-analysis
Long intragenic non-coding RNA p53-induced transcript (LINC-PINT) as a novel prognosis indicator and therapeutic target in cancer.
He T et al.·Biomed Pharmacother
2021Review
Functional Mechanism and Clinical Implications of lncRNA LINC-PINT in Delayed Fracture Healing.
Ma X et al.·J Invest Surg
2024Functional
Long noncoding RNA LINC-PINT is inhibited in gastric cancer and predicts poor survival.
Feng H et al.·J Cell Biochem
2019
Long noncoding RNA LINC-PINT regulates laryngeal carcinoma cell stemness and chemoresistance through miR-425-5p/PTCH1/SHH axis.
Yuan Z et al.·J Cell Physiol
2019
LINC-PINT expression and rs1059698 polymorphism associate with chemoradiotherapy efficacy in Chinese nasopharyngeal carcinoma patients.
Ma S et al.·BMC Cancer
2025Cohort
Assessment of LINC-PINT genetic polymorphisms and esophageal squamous cell carcinoma risk in the Hainan Han population.
Tu R et al.·Ann Med
2024
LncRNA LINC-PINT Inhibits Malignant Behaviors of Laryngeal Squamous Cell Carcinoma Cells via Inhibiting ZEB1.
Yang X et al.·Pathol Oncol Res
2021
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools