LGI2

Chr 4

leucine rich repeat LGI family member 2

Also known as: LGIL2

NCBI Gene: 55203ENSG00000153012UniProt: Q8N0V4OMIM: 608301

Predicted to be involved in inhibitory synapse assembly. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

OMIMResearchGenerating clinical summary…
0
Active trials
3
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.89
LOEUF
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.89LOEUF
pLI 0.000
Z-score 1.95
OE 0.56 (0.36–0.89)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
1.63Z-score
OE missense 0.74 (0.66–0.82)
230 obs / 311.0 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.56 (0.36–0.89)
0≤0.351.4
Missense OE?0.74 (0.66–0.82)
0≤0.61.4
Synonymous OE?0.97
0≤1.21.6
LoF obs/exp: 13 / 23.1Missense obs/exp: 230 / 311.0Syn Z: 0.25

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

LGI2 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients