LGALS8
Chr 1galectin 8
The protein encoded by this gene is a beta-galactoside-binding lectin that functions as a cellular sensor of membrane damage, detecting pathogens by binding to exposed galactoside ligands and targeting them for autophagy to restrict bacterial and viral infections. This gene has very low constraint against loss-of-function variants (pLI near 0, LOEUF >1), and no established Mendelian diseases have been associated with LGALS8 mutations to date. The gene is widely expressed and involved in cell adhesion, growth regulation, and immune defense mechanisms.
Some data sources returned errors (1)
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Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Tolerant to missense variation
The highest-scoring mechanism for this gene is dominant-negative.
Note: In-silico variant effect predictors (SIFT, PolyPhen, REVEL, CADD) may underestimate pathogenicity of missense variants in genes with GOF or DN mechanisms. Consider functional evidence and clinical context.
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
LGALS8 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools