LGALS8

Chr 1

galectin 8

Also known as: Gal-8, PCTA-1, PCTA1, Po66-CBP

NCBI Gene: 3964 ENSG00000116977 UniProt: O00214

The protein encoded by this gene is a beta-galactoside-binding lectin that functions as a cellular sensor of membrane damage, detecting pathogens by binding to exposed galactoside ligands and targeting them for autophagy to restrict bacterial and viral infections. This gene has very low constraint against loss-of-function variants (pLI near 0, LOEUF >1), and no established Mendelian diseases have been associated with LGALS8 mutations to date. The gene is widely expressed and involved in cell adhesion, growth regulation, and immune defense mechanisms.

ResearchSummary from RefSeq, UniProt

This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

1.06

LOEUF

Mechanism· predicted

Some data sources returned errors (1)

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