LDLRAD3

Chr 11

low density lipoprotein receptor class A domain containing 3

Also known as: LRAD3

NCBI Gene: 143458ENSG00000179241UniProt: Q86YD5

Predicted to enable amyloid-beta binding activity. Predicted to be involved in receptor-mediated endocytosis. Predicted to act upstream of or within regulation of protein processing. Predicted to be located in endomembrane system and membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
9
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.83
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.83LOEUF
pLI 0.016
Z-score 2.00
OE 0.39 (0.20–0.83)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
0.70Z-score
OE missense 0.86 (0.77–0.98)
184 obs / 212.9 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.39 (0.20–0.83)
0≤0.351.4
Missense OE?0.86 (0.77–0.98)
0≤0.61.4
Synonymous OE?0.80
0≤1.21.6
LoF obs/exp: 5 / 12.7Missense obs/exp: 184 / 212.9Syn Z: 1.55

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

LDLRAD3 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients