LCN2
Chr 9lipocalin 2
The LCN2 protein regulates cellular iron trafficking by binding iron through association with siderophores and either delivering iron to cells or removing it depending on the iron-bound state, and also functions in innate immunity by sequestering iron from bacterial siderophores. Mutations cause autosomal recessive intellectual developmental disorder with behavioral abnormalities and craniofacial dysmorphism. This gene shows no constraint against loss-of-function variants in the general population.
Some data sources returned errors (1)
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Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Tolerant to missense variation
The highest-scoring mechanism for this gene is dominant-negative.
Note: In-silico variant effect predictors (SIFT, PolyPhen, REVEL, CADD) may underestimate pathogenicity of missense variants in genes with GOF or DN mechanisms. Consider functional evidence and clinical context.
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
LCN2 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
Effect of a Short-term Multi-strain Probiotic Supplementation in Endurance Athletes
RECRUITINGConstruction and Evaluation of Tumor Immunotherapy and Organ Damage Early Warning System Based on Multi-omics
RECRUITINGBody Fat as Determinant of Female Gonadal Dysfunction
RECRUITINGOslo Footballplayers Iron Supplementation and Training (FIT) Study
ACTIVE NOT RECRUITINGDIagnoSing Care hOme UTI Study
RECRUITINGCytokines, Neuroplasticity Modulators, and Biomarkers in Spinal Canal Stenosis and Endoscopic Decompression
NOT YET RECRUITINGGoat Milk-Derived Formula vs. Undiluted Goat Milk in Infants Unable to Exclusively Breastfeed: Growth and Biomarker Analysis
RECRUITINGAntihypertensive Mechanisms of Minocycline in Resistant Hypertension
RECRUITINGExternal Resources
Links to major genomics databases and tools