LCN15

Chr 9

lipocalin 15

Also known as: PRO6093, UNQ2541

NCBI Gene: 389812ENSG00000177984UniProt: Q6UWW0

This gene encodes a protein predicted to bind small molecules in the extracellular space, but its specific function remains unclear. The gene shows low constraint against loss-of-function variants (pLI 0.004, LOEUF 1.13), and no definitive disease associations have been established in the provided data. Clinical significance of variants in LCN15 is currently uncertain.

ResearchSummary from RefSeq
MultiplemechanismLOEUF 1.13
Clinical Summary— LCN15
⚡
Population Constraint (gnomAD)
Low constraint (pLI 0.00) — loss-of-function variants are relatively tolerated in the population.
📋
ClinVar Variants
71 unique Pathogenic / Likely Pathogenic· 28 VUS of 108 total submissions
Explore recent and relevant literature in Research Assistant →

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint
1.13LOEUF
pLI 0.004
Z-score 1.31
OE 0.54 (0.28–1.13)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint
0.41Z-score
OE missense 0.89 (0.75–1.05)
92 obs / 103.8 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios
LoF OE0.54 (0.28–1.13)
0≤0.351.4
Missense OE0.89 (0.75–1.05)
0≤0.61.4
Synonymous OE1.17
0≤1.21.6
LoF obs/exp: 5 / 9.3Missense obs/exp: 92 / 103.8Syn Z: -0.93
DN
0.7327th %ile
GOF
0.6930th %ile
LOF
0.1598th %ile

This gene has evidence for multiple mechanisms of pathogenicity (dominant-negative and gain-of-function). Both the Badonyi & Marsh prediction and the broader genomic evidence point to dominant-negative as the predominant mechanism. Different variants in this gene may act through different mechanisms — interpret in context of the specific variant.

DNprediction above median
GOFprediction above median

Note: In-silico variant effect predictors (SIFT, PolyPhen, REVEL, CADD) may underestimate pathogenicity of missense variants in genes with GOF or DN mechanisms. Consider functional evidence and clinical context.

Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.

ClinVar Variant Classifications

108 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic68
Likely Pathogenic3
VUS28
Likely Benign4
Benign1
Conflicting2
68
Pathogenic
3
Likely Pathogenic
28
VUS
4
Likely Benign
1
Benign
2
Conflicting

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
0
0
68
0
68
Likely Pathogenic
0
0
3
0
3
VUS
0
21
7
0
28
Likely Benign
0
4
0
0
4
Benign
0
0
1
0
1
Conflicting
—2
Total025790106

LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

LCN15 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →
Clinical Literature
Open Research Assistant →
Full-Text Mentions
NLP-detected gene mentions in article bodies · via PubTator3
PubTator3
Top 5 full-text resultsSearch PubTator3 ↗
Key Publications
Landmark & review papers · by relevance
PubMed
Top 4 results · since 2015Search PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC

No open access results found

Top 5 resultsSearch Europe PMC ↗

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients