LCIIAR
Chr 15lung cancer immune cell infiltration associated lncRNA
56
ClinVar variants
39
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— LCIIAR
📋
ClinVar Variants
39 Pathogenic / Likely Pathogenic· 14 VUS of 56 total submissions
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
56 submitted variants in ClinVar
Classification Summary
Pathogenic36
Likely Pathogenic3
VUS14
Likely Benign2
Conflicting1
36
Pathogenic
3
Likely Pathogenic
14
VUS
2
Likely Benign
1
Conflicting
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | — | — | — | — | 36 |
Likely Pathogenic | — | — | — | — | 3 |
VUS | — | — | — | — | 14 |
Likely Benign | — | — | — | — | 2 |
Benign | — | — | — | — | 0 |
Conflicting | — | 1 | |||
| Total | — | 56 | |||
Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
LCIIAR · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
OMIM — Genotype-Phenotype
No OMIM entries found.
External Resources
Links to major genomics databases and tools
Variant Interpretation
Population Databases
Gene Resources
Expert Curation
ClinGen
Expert-curated gene-disease validity
GenCC
Gene Curation Coalition — multi-curator classifications
Orphanet
Rare disease encyclopedia and gene-disease associations
PanelApp
Gene panels for rare disease diagnostics (Genomics England)
LOVD
Leiden Open Variation Database — variant listings
GeneReviews
Expert-authored summaries of heritable conditions (NCBI)
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
Perfluorooctanesulfonic acid (PFOS) induced cancer related DNA methylation alterations in human breast cells: A whole genome methylome study.
Pierozan P et al.·Sci Total Environ
2024
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Distinct Lung Adenocarcinoma-Associated Microbiota Are Associated with Inflammatory Immune Landscapes and Tumor Cell Proliferation via LCIIAR-ISG15 Regulatory Networks.
Liu S et al.·Cancer Manag Res
2025🔓 Open Access
Identification and Validation of Long Non-Coding RNA LCIIAR as a Biomarker in LUAD.
Ren W et al.·Front Oncol
2022🔓 Open Access
Top 5 resultsSearch Europe PMC ↗
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools
Variant Interpretation
Population Databases
Gene Resources
Expert Curation
ClinGen
Expert-curated gene-disease validity
GenCC
Gene Curation Coalition — multi-curator classifications
Orphanet
Rare disease encyclopedia and gene-disease associations
PanelApp
Gene panels for rare disease diagnostics (Genomics England)
LOVD
Leiden Open Variation Database — variant listings
GeneReviews
Expert-authored summaries of heritable conditions (NCBI)