KLRF2

Chr 12

killer cell lectin like receptor F2

Also known as: NKp65

NCBI Gene: 100431172ENSG00000256797UniProt: D3W0D1OMIM: 618814

Enables protein homodimerization activity. Predicted to be involved in natural killer cell degranulation and positive regulation of cytokine production. Predicted to act upstream of or within natural killer cell activation and positive regulation of natural killer cell mediated cytotoxicity. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

OMIMResearchGenerating clinical summary…
0
Active trials
1
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.93
LOEUF
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.93LOEUF
pLI 0.000
Z-score -1.35
OE 1.49 (0.94–1.93)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.19Z-score
OE missense 0.94 (0.79–1.14)
79 obs / 83.8 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?1.49 (0.94–1.93)
0≤0.351.4
Missense OE?0.94 (0.79–1.14)
0≤0.61.4
Synonymous OE?0.69
0≤1.21.6
LoF obs/exp: 13 / 8.7Missense obs/exp: 79 / 83.8Syn Z: 1.35

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

KLRF2 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients