KLHL36
Chr 16kelch like family member 36
Also known as: C16orf44
Enables cullin family protein binding activity. Predicted to be involved in protein ubiquitination. [provided by Alliance of Genome Resources, Jul 2025]
ResearchGenerating clinical summary…
LOEUF 0.40
Clinical Summary— KLHL36
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Population Constraint (gnomAD)
Moderately constrained gene (pLI 0.81) — some intolerance to loss-of-function variants.
Some data sources returned errors (1)
omim: Error: OMIM fetch failed: 429
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Moderate LoF intolerance
LoF Constraint?
0.40LOEUF
pLI 0.807
Z-score 3.67
OE 0.17 (0.09–0.40)
More LoF-intolerant than ~75% of genes
Missense Constraint?
1.12Z-score
OE missense 0.85 (0.78–0.93)
377 obs / 443.2 exp
Mild missense constraint
Observed / Expected Ratios?
LoF OE?0.17 (0.09–0.40)
0≤0.351.4
Missense OE?0.85 (0.78–0.93)
0≤0.61.4
Synonymous OE?1.23
0≤1.21.6
LoF obs/exp: 4 / 23.0Missense obs/exp: 377 / 443.2Syn Z: -2.63
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
KLHL36 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools