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KLF9-DT

Chr 9

KLF9 divergent transcript

NCBI Gene: 101927086

I cannot provide a clinical summary for KLF9-DT as no information about this gene's protein function, associated diseases, or inheritance pattern was provided in the data below the instructions. To write an accurate clinical summary following the strict rules requiring only supported information, I would need details about what protein this gene encodes, what conditions result from mutations, and the inheritance pattern.

Research
Clinical Summary— KLF9-DT
📋
ClinVar Variants
21 unique Pathogenic / Likely Pathogenic· 124 VUS of 185 total submissions
Explore recent and relevant literature in Research Assistant →
Some data sources returned errors (2)

ensembl: Error: Ensembl fetch failed: 400 for https://rest.ensembl.org/lookup/symbol/homo_sapiens/KLF9-DT?content-type=application/json&expand=1

gnomad: Error: Gene not found

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

185 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic17
Likely Pathogenic4
VUS124
Likely Benign22
Benign9
Conflicting4
17
Pathogenic
4
Likely Pathogenic
124
VUS
22
Likely Benign
9
Benign
4
Conflicting

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
0
0
17
0
17
Likely Pathogenic
0
1
3
0
4
VUS
2
121
1
0
124
Likely Benign
0
9
2
11
22
Benign
0
4
2
3
9
Conflicting
—4
Total21352514180

LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

KLF9-DT · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients