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KLF9-DT

Chr 9

KLF9 divergent transcript

NCBI Gene: 101927086

I cannot provide a clinical summary for KLF9-DT as no information about this gene's protein function, associated diseases, or inheritance pattern was provided in the data below the instructions. To write an accurate clinical summary following the strict rules requiring only supported information, I would need details about what protein this gene encodes, what conditions result from mutations, and the inheritance pattern.

Research

ResearchGenerating clinical summary…

Clinical Summary— KLF9-DT

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ClinVar Variants

1 unique Pathogenic / Likely Pathogenic· 124 VUS of 165 total submissions

Explore recent and relevant literature in Research Assistant →

Some data sources returned errors (2)

ensembl: Error: Ensembl fetch failed: 400 for /lookup/symbol/homo_sapiens/KLF9-DT?content-type=application/json&expand=1

gnomad: Error: Gene not found

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

165 submitted variants in ClinVar

ClinVar

Classification Summary

Likely Pathogenic1

VUS124

Likely Benign22

Benign9

Conflicting4

Likely Pathogenic

124

VUS

Likely Benign

Benign

Conflicting

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories

Classification	LoF	Missense + Inframe	Non-coding	Synonymous	Total
Pathogenic	0	0	0	0	0
Likely Pathogenic	0	1	0	0	1
VUS	2	122	0	0	124
Likely Benign	0	9	2	11	22
Benign	0	4	2	3	9
Conflicting	—				4
Total	2	136	4	14	160

LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly

View in ClinVar →

20 pathogenic / likely-pathogenic (of 21) ClinVar copy-number / structural variants overlap KLF9-DT — these span large chromosomal regions, not the gene specifically, and are excluded from the counts above. Explore in CNV tools →