KIF3A

Chr 5

kinesin family member 3A

Also known as: FLA10, KLP-20

NCBI Gene: 11127ENSG00000131437UniProt: Q9Y496OMIM: 604683

Enables protein phosphatase binding activity; small GTPase binding activity; and spectrin binding activity. Involved in protein localization to cell junction and protein transport. Located in centriole; centrosome; and spindle microtubule. Part of kinesin II complex. Implicated in allergic disease and asthma. Biomarker of asthma and silicosis. [provided by Alliance of Genome Resources, Jun 2026]

OMIMResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant
This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.
0
Active trials
20
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.34
LOEUF· LoF intol.
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Dual constrained — LoF & missense intolerant
LoF Constraint?
0.34LOEUF
pLI 0.898
Z-score 4.68
OE 0.18 (0.10–0.34)
Highly constrained

Highly LoF-intolerant (top ~10% of genes)

Missense Constraint?
3.09Z-score
OE missense 0.55 (0.49–0.62)
209 obs / 378.2 exp
Constrained

Highly missense-constrained (top ~0.1%)

Observed / Expected Ratios?
LoF OE?0.18 (0.10–0.34)
0≤0.351.4
Missense OE?0.55 (0.49–0.62)
0≤0.61.4
Synonymous OE?0.87
0≤1.21.6
LoF obs/exp: 7 / 38.2Missense obs/exp: 209 / 378.2Syn Z: 1.09

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

KIF3A · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients