KIF26A

Chr 14

kinesin family member 26A

Also known as: CDCBM11

NCBI Gene: 26153 ENSG00000066735 UniProt: Q9ULI4

KIF26A encodes an atypical kinesin that binds microtubules and regulates cerebral cortical development by controlling neurite growth and radial migration of cortical excitatory neurons. Biallelic mutations cause autosomal recessive complex cortical dysplasia with other brain malformations, affecting brain development and structure. The gene is highly constrained against loss-of-function variants (LOEUF 0.47), indicating strong evolutionary pressure to maintain protein function.

ResearchSummary from RefSeq, OMIM, UniProt

Predicted to enable microtubule binding activity. Involved in cerebral cortex development; regulation of neuron migration; and regulation of neuron projection development. Predicted to be located in cytosol. Implicated in complex cortical dysplasia with other brain malformations 11. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…

Primary Disease Associations & Inheritance

UniProtCortical dysplasia, complex, with other brain malformations 11

Clinical highlights

Gene-disease validity (ClinGen)

complex cortical dysplasia with other brain malformations · ARStrongappropriate for clinical testing

Interpreting a novel variant

This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

0.47

LOEUF

Mechanism· predicted

Some data sources returned errors (1)

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