KIF20B

Chr 10

kinesin family member 20B

Also known as: CT90, KRMP1, MPHOSPH1, MPP-1, MPP1

NCBI Gene: 9585ENSG00000138182UniProt: Q96Q89OMIM: 605498

Enables several functions, including ATP hydrolysis activity; WW domain binding activity; and plus-end-directed microtubule motor activity. Involved in positive regulation of cell population proliferation and positive regulation of cytokinesis. Located in several cellular components, including microtubule cytoskeleton; midbody; and nuclear lumen. [provided by Alliance of Genome Resources, Jul 2025]

OMIMResearchGenerating clinical summary…
0
Active trials
7
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.69
LOEUF
DN
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.69LOEUF
pLI 0.000
Z-score 4.15
OE 0.55 (0.44–0.69)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
-0.60Z-score
OE missense 1.06 (1.00–1.12)
893 obs / 843.7 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.55 (0.44–0.69)
0≤0.351.4
Missense OE?1.06 (1.00–1.12)
0≤0.61.4
Synonymous OE?1.06
0≤1.21.6
LoF obs/exp: 53 / 97.2Missense obs/exp: 893 / 843.7Syn Z: -0.77

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

KIF20B · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients