KDM4F

Chr 11

lysine demethylase 4F (putative)

Also known as: JMJD2F

NCBI Gene: 100129053 ENSG00000255855 UniProt: A0A1W2PPD8

Predicted to enable histone H3K9 demethylase activity. Predicted to be involved in chromatin remodeling and regulation of gene expression. Predicted to be active in chromatin and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Research

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

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LOEUF

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Mechanism

Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

Background carrier burden — how many people carry a rare variant somewhere in KDM4F?

gnomAD v4 · ~731k individuals · PASS only

Rare means allele frequency under

Rare missense

1 in 41

757 rare PASS variants

Rare truncating (LoF)

1 in 570

86 rare PASS variants

Rare synonymous (reference)

1 in 110

285 rare PASS variants

Truncating variants are far rarer here than missense — that gap, in human units, is what constraint means for KDM4F. A background rate for each class, not the frequency of any particular variant; thin-coverage exons undercount.

By genetic ancestry · 9 gnomAD groups · rare = under 0.1% in that group

Group	People	Missense	Truncating
European (non-Finnish)	~556k	1 in 59	1 in 790
South Asian	~43k	1 in 40	1 in 340
Remaining (unassigned)	~30k	1 in 32	1 in 880
European (Finnish)	~27k	1 in 220	≈ 1 in 7,500
Admixed American	~22k	1 in 39	1 in 1,000
African / African American	~21k	1 in 50	1 in 280
East Asian	~20k	1 in 55	1 in 420
Ashkenazi Jewish	~13k	1 in 160	none seen
Middle Eastern	~2,884	1 in 45	1 in 340

Each group is summed over the variants that are rare in that group. Grey ≈ figures rest on fewer than five expected carriers — too few to distinguish groups. Differences mostly reflect how many people were sampled and how much variation each ancestry carries, not disease risk.

Exome coverage (gnomAD): 0 of 1 coding exons well covered in gnomAD exomes; exon 1 marginal. Genomes: all 1.? see exons ↓