JPT1
Chr 17Jupiter microtubule associated homolog 1
Also known as: ARM2, HN1, HN1A
Located in several cellular components, including intercellular bridge; microtubule cytoskeleton; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Clinical Summary— JPT1
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Population Constraint (gnomAD)
Low constraint (pLI 0.00) — loss-of-function variants are relatively tolerated in the population.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Tolerant — LoF & missense variants common in population
LoF Constraint?LOEUF (Loss-of-function Observed/Expected Upper bound Fraction) is the upper bound of the 90% CI for LoF OE — the preferred gnomAD v4 metric. Lower = more intolerant to LoF. LOEUF < 0.35 = highly constrained.
1.28LOEUF
pLI 0.003
Z-score 1.03
OE 0.61 (0.32–1.28)
Highly tolerant — LoF variants common in population
Missense Constraint?Missense Z-score: standard deviations fewer missense variants observed vs. expected. Z > 3.09 (p < 0.001) = gene does not tolerate missense variation. OE missense < 0.6 is also considered constrained.
0.60Z-score
OE missense 0.83 (0.70–1.00)
84 obs / 100.9 exp
Mild missense constraint
Observed / Expected Ratios?Shaded band = 90% confidence interval. Vertical tick = point estimate. Grey threshold line = gnomAD constraint cutoff for that variant class.
LoF OE?Ratio of observed to expected LoF variants. Upper CI bound (LOEUF) ≤ 0.35 = strong LoF constraint signal.0.61 (0.32–1.28)
0≤0.351.4
Missense OE?Ratio of observed to expected missense variants. OE ≤ 0.6 = fewer missense variants than expected by chance.0.83 (0.70–1.00)
0≤0.61.4
Synonymous OE?Control metric — synonymous variants are largely neutral and expected near OE = 1.0. Significant deviation may indicate annotation issues.0.78
0≤1.21.6
LoF obs/exp: 5 / 8.2Missense obs/exp: 84 / 100.9Syn Z: 1.05
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
JPT1 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →Clinical Literature
Landmark / reviewRecent case evidence
Full-Text Mentions
NLP-detected gene mentions in article bodies · via PubTator3
Single-Cell RNA Sequencing Integrated with Bulk-RNA Sequencing Analysis Reveals Prognostic Signatures Based on PANoptosis in Hepatocellular Carcinoma
Wang J et al.·J Hepatocell Carcinoma
2025
Rationally Designed Peptoid Inhibitors of Amyloid-beta Oligomerization.
Waugh ML et al.·Chembiochem
2024
Insights into the E2F target genes in breast cancer: associations of pathway genes with prognosis and immune cell filtration based on in silico and ex vivo analyses.
Nikonezhad B et al.·Cancer Cell Int
2025
Modulating the RAGE-Induced Inflammatory Response: Peptoids as RAGE Antagonists
Waugh ML et al.·Chembiochem
2023
HN1 interacts with gamma-tubulin to regulate centrosomes in advanced prostate cancer cells.
Varisli L et al.·Cell Cycle
2021
Top 5 full-text resultsSearch PubTator3 ↗
Key Publications
Landmark & review papers · by relevance
Circ-PGPEP1 augments renal cell carcinoma proliferation, Warburg effect, and distant metastasis.
Wang P et al.·Acta Biochim Pol
2023
Role of hematological and neurological expressed 1 (HN1) in human cancers.
Li H et al.·Crit Rev Oncol Hematol
2024Review
Top 4 results · since 2015Search PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
The role of JPT1 in hepatocellular carcinoma: tumor progression, microtubule dynamics regulation, and potential mechanisms within the immune microenvironment.
Lu Y et al.·Discov Oncol
2025Open AccessFunctional
Circular RNA LPAR3 targets JPT1 via microRNA-513b-5p to facilitate glycolytic activation but repress prostate cancer radiosensitivity.
Chen YY et al.·Acta Biochim Pol
2023
LncRNA HOXA11-AS promotes cell growth by sponging miR-24-3p to regulate JPT1 in prostate cancer.
Cheng Y et al.·Eur Rev Med Pharmacol Sci
2021
Jupiter microtubule-associated homolog 1 (JPT1): A predictive and pharmacodynamic biomarker of metformin response in endometrial cancers.
Bateman NW et al.·Cancer Med
2020Open Access
Top 5 resultsSearch Europe PMC ↗
External Resources
Links to major genomics databases and tools