INTS15

Chr 7

integrator complex subunit 15

Also known as: C7orf26

NCBI Gene: 79034 ENSG00000146576 UniProt: Q96N11

The protein is a component of the integrator complex that terminates RNA polymerase II transcription and processes non-coding RNAs, serving as a bridge between different integrator modules and helping recruit transcription factors at promoters. Mutations cause autosomal dominant neurodevelopmental disorder with developmental delay, intellectual disability, and behavioral abnormalities. The gene is highly constrained against loss-of-function variants (pLI 0.98, LOEUF 0.30), indicating that even single functional copies are critical for normal development.

ResearchSummary from RefSeq, UniProt

Involved in RNA polymerase II transcription initiation surveillance and regulation of transcription elongation by RNA polymerase II. Part of INTAC complex and integrator complex. Is active in chromosome and nucleus. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant

This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

0.30

LOEUF· LoF intol.

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Mechanism

Some data sources returned errors (1)

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