INO80E

Chr 16

INO80 complex subunit E

Also known as: CCDC95

NCBI Gene: 283899ENSG00000169592UniProt: Q8NBZ0

Involved in several processes, including chromatin remodeling; regulation of chromosome organization; and regulation of nucleobase-containing compound metabolic process. Located in nucleolus and nucleoplasm. Part of Ino80 complex. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
12
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.95
LOEUF
DN
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.95LOEUF
pLI 0.009
Z-score 1.69
OE 0.45 (0.23–0.95)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
-0.25Z-score
OE missense 1.06 (0.93–1.22)
138 obs / 129.8 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.45 (0.23–0.95)
0≤0.351.4
Missense OE?1.06 (0.93–1.22)
0≤0.61.4
Synonymous OE?1.18
0≤1.21.6
LoF obs/exp: 5 / 11.1Missense obs/exp: 138 / 129.8Syn Z: -1.07

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

INO80E · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients