INO80D
Chr 2INO80 complex subunit D
The protein is a regulatory component of the INO80 chromatin remodeling complex, which controls gene transcription, DNA replication, and DNA repair. This gene is highly constrained against loss-of-function mutations (pLI 1.0, LOEUF 0.23), suggesting mutations would likely cause severe developmental disorders, though specific associated diseases have not yet been clearly established in the literature. The inheritance pattern for potential INO80D-related conditions remains to be determined.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly LoF-intolerant (top ~10% of genes)
Moderately missense-constrained (top ~2.5%)
The highest-scoring mechanism for this gene is loss-of-function (haploinsufficiency).
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312. Mechanism ranking also informed by gnomAD constraint, ClinVar, and ClinGen data.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
INO80D · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools