INO80C
Chr 18INO80 complex subunit C
Also known as: C18orf37, IES6, hIes6
INO80C encodes a core component of the INO80 chromatin remodeling complex that regulates gene transcription, DNA replication, and DNA repair. The gene shows low constraint against loss-of-function variants (pLI 0.0004, LOEUF 1.416), suggesting that complete loss of function may be tolerated. Currently, no established human genetic disorders have been definitively linked to INO80C mutations in the medical literature.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Tolerant to missense variation
The highest-scoring mechanism for this gene is loss-of-function (haploinsufficiency).
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
INO80C · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools