INHBE
Chr 12inhibin subunit beta E
This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate an inhibin beta subunit. Inhibins have been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. This gene may be upregulated under conditions of endoplasmic reticulum stress, and this protein may inhibit cellular proliferation and growth in pancreas and liver. [provided by RefSeq, Sep 2016]
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Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
INHBE · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
A SkeleTal Muscle Recovery Intervention With Dietary Protein in Heart Failure
RECRUITINGCardiac Evaluation in Hereditary Hemorrhagic Telangiectasia
NOT YET RECRUITINGEvaluation of the BMPR2-Activin Signaling Pathway in Group II Pulmonary Hypertension.
RECRUITINGExternal Resources
Links to major genomics databases and tools