ING4
Chr 12inhibitor of growth family member 4
Also known as: my036, p29ING4
This gene encodes a tumor suppressor protein that functions as a component of HBO1 complexes to acetylate histone H3 and regulate chromatin remodeling, while also modulating cell proliferation pathways and enhancing apoptosis. Pathogenic variants in ING4 have been associated with neurodevelopmental disorders, though the clinical spectrum and inheritance patterns are still being characterized. The gene shows low constraint against loss-of-function variants, suggesting tolerance to haploinsufficiency.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Typical tolerance to LoF variation
Mild missense constraint
The highest-scoring mechanism for this gene is dominant-negative.
Note: In-silico variant effect predictors (SIFT, PolyPhen, REVEL, CADD) may underestimate pathogenicity of missense variants in genes with GOF or DN mechanisms. Consider functional evidence and clinical context.
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
ING4 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools