ING4

Chr 12

inhibitor of growth family member 4

Also known as: my036, p29ING4

NCBI Gene: 51147 ENSG00000111653 UniProt: Q9UNL4

This gene encodes a tumor suppressor protein that functions as a component of HBO1 complexes to acetylate histone H3 and regulate chromatin remodeling, while also modulating cell proliferation pathways and enhancing apoptosis. Pathogenic variants in ING4 have been associated with neurodevelopmental disorders, though the clinical spectrum and inheritance patterns are still being characterized. The gene shows low constraint against loss-of-function variants, suggesting tolerance to haploinsufficiency.

ResearchSummary from RefSeq, UniProt

This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. [provided by RefSeq, Jul 2008]

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

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P/LP missense

0.74

LOEUF

Mechanism· predicted

Some data sources returned errors (1)

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