ING1
Chr 13inhibitor of growth family member 1
Also known as: p24ING1c, p33, p33ING1, p33ING1b, p47, p47ING1a
The ING1 protein is a nuclear tumor suppressor that cooperates with p53 in regulating cell growth by modulating p53-dependent transcriptional activation. Mutations cause squamous cell carcinoma of the head and neck, which occurs somatically rather than being inherited. The gene is not highly constrained against loss-of-function variants, consistent with its role in somatic rather than germline disease.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Typical tolerance to LoF variation
Mild missense constraint
ClinVar Variant Classifications
100 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | 0 | 0 | 73 | 0 | 73 |
Likely Pathogenic | 0 | 0 | 1 | 0 | 1 |
VUS | 0 | 14 | 8 | 0 | 22 |
Likely Benign | 0 | 1 | 0 | 0 | 1 |
Benign | 1 | 0 | 0 | 1 | 2 |
| Total | 1 | 15 | 82 | 1 | 99 |
LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
ING1 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools