INCR1

Chr 9

interferon stimulated noncoding RNA 1

I cannot provide a clinical summary for INCR1 as no information about this gene's protein function, associated diseases, or inheritance pattern was provided in the data below the instructions. To write an accurate clinical summary following the specified guidelines, I would need details about the protein's cellular function, the phenotypes/diseases caused by mutations in this gene, and the inheritance pattern observed in affected families.

Research

ResearchGenerating clinical summary…

Clinical Summary— INCR1

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ClinVar Variants

53 VUS of 70 total submissions

Explore recent and relevant literature in Research Assistant →

Some data sources returned errors (1)

gnomad: Error: Gene not found

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

70 submitted variants in ClinVar

ClinVar

Classification Summary

VUS53

Likely Benign4

Benign2

VUS

Likely Benign

Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories

Classification	LoF	Missense + Inframe	Non-coding	Total
Pathogenic	0	0	0	0
Likely Pathogenic	0	0	0	0
VUS	1	52	0	53
Likely Benign	0	4	0	4
Benign	0	0	2	2
Total	1	56	2	59

LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly

View in ClinVar →

79 pathogenic / likely-pathogenic (of 83) ClinVar copy-number / structural variants overlap INCR1 — these span large chromosomal regions, not the gene specifically, and are excluded from the counts above. Explore in CNV tools →