IMPACT
Chr 18impact RWD domain protein
Also known as: RWDD5
Predicted to enable protein sequestering activity. Predicted to be involved in several processes, including GCN2-mediated signaling; cellular response to amino acid starvation; and regulation of gene expression. Predicted to act upstream of or within negative regulation of protein phosphorylation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Some data sources returned errors (1)
omim: Error: OMIM fetch failed: 429
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
IMPACT · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
The NorCUP Trial: Improving Prognosis and Personalized Treatment in Cancer of Unknown Primary (CUP)
NOT YET RECRUITINGEarly Genomic Testing for Inherited Bleeding Disorders
RECRUITINGCAMPSIITE™ RGX-121 Gene Therapy in Subjects With MPS II (Hunter Syndrome)
ACTIVE NOT RECRUITINGCOVID-19 Transmission and Morbidity in Malawi
RECRUITINGA Multi-omic Approach to the Identification of Novel Biomarkers in Early Charcot-Marie-Tooth 1A Disease (CMT1A)
RECRUITINGEvolution of the Cognitive Profile and Quality of Life of Adult Patients Suffering From Severe Migraines Under Preventive Treatment
NOT YET RECRUITINGGrowing Up in Multifactorial Risk Conditions
ENROLLING BY INVITATIONHSV-tk + Valacyclovir Therapy in Combination With Brachytherapy for Recurrent Prostate Cancer
RECRUITINGNatural History in Fabry Disease With IVS4+919G>A Mutations
ACTIVE NOT RECRUITINGPhase I Study of CTL Anti-DP Infusion Post-hematopoietic Stem Cell Transplantation
RECRUITINGStudy to Evaluate the Efficacy and Safety of PF-07055480 / Giroctocogene Fitelparvovec Gene Therapy in Moderately Severe to Severe Hemophilia A Adults
ACTIVE NOT RECRUITINGUltrasound Guided Block of Stellate Ganglion Versus Greater Occipital Nerve in Resistant Migraine and Correlation to Calcitonin Gene Related Peptide
RECRUITINGExternal Resources
Links to major genomics databases and tools