IL5
Chr 5interleukin 5
Also known as: EDF, IL-5, TRF
This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013]
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Tolerant to missense variation
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
IL5 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
High Definition Medicine for Solid Tumors Oncology
RECRUITINGMulti-Strain Probiotics Supplementation With Standard Care in Mild to Moderate Ulcerative Colitis
RECRUITINGEfficacy and Safety of Stapokibart in Non-Allergic Rhinitis With Eosinophilia Syndrome
NOT YET RECRUITINGThe CATALINA Study
RECRUITINGHuman Milk Oligosaccharides (HMOs) and Gut Microbiota, Immune System in Antarctica
ENROLLING BY INVITATIONBiomarkers in Systemic Histiocytosis
NOT YET RECRUITINGRegulation of Inflammatory Genes in Psoriasis
RECRUITINGeGPA and Local Inflammation Within the Ear, Nose and Throat Area
RECRUITINGPrediction of Radiotherapy Efficacy in Patients With Triple-negative Breast Cancer
ACTIVE NOT RECRUITINGCytokine Response to Abdominal Wall Reconstruction
RECRUITINGA Phase I/IIa Study of GKL-006 Injection in Patients With Advanced Pancreatic Cancer
ACTIVE NOT RECRUITINGThe Influence of Mepolizumab on Structural and Inflammatory Cells in Severe Eosinophilic Asthma
ACTIVE NOT RECRUITINGExternal Resources
Links to major genomics databases and tools