IL32

Chr 16

interleukin 32

Also known as: IL-32alpha, IL-32beta, IL-32delta, IL-32gamma, NK4, TAIF, TAIFa, TAIFb

NCBI Gene: 9235 ENSG00000008517 UniProt: P24001

This gene encodes a cytokine that induces production of TNF-alpha from macrophages and activates NF-kappa-B and p38 MAPK signaling pathways in immune responses. Mutations cause autosomal dominant autoinflammatory disease with immunodeficiency. The gene is highly intolerant to loss-of-function mutations, suggesting complete loss of protein function may be incompatible with normal development.

ResearchSummary from RefSeq, UniProt

This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNFalpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

1.92

LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (1)