IL27
Chr 16interleukin 27
Also known as: IL-27, IL-27A, IL27A, IL27p28, IL30, p28
The IL27 protein associates with EBI3 to form the IL-27 cytokine complex, which regulates T-helper cell development, suppresses T-cell proliferation, stimulates cytotoxic T-cell activity, and has diverse effects on innate immune cells including driving clonal expansion of naive CD4+ T-cells and synergizing with IL-12 to trigger interferon-gamma production. Mutations in IL27 cause immunodeficiency with autosomal recessive inheritance, affecting immune system function. This gene shows high constraint against loss-of-function variants, indicating it is essential for normal cellular function.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
More LoF-intolerant than ~75% of genes
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
IL27 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools