IL20RB

Chr 3

interleukin 20 receptor subunit beta

Also known as: DIRS1, FNDC6, IL-20R-beta, IL-20R2, IL-20RB

NCBI Gene: 53833 ENSG00000174564 UniProt: Q6UXL0 OMIM: 605621

IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619) (Blumberg et al., 2001 [PubMed 11163236]).[supplied by OMIM, Feb 2009]

OMIM Research

IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619) (Blumberg et al., 2001 [PubMed 11163236]).[supplied by OMIM, Feb 2009]

OMIM ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

1.30

LOEUF

Multiple*

Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD

Tolerant — LoF & missense variants common in population

LoF Constraint?

1.30LOEUF

pLI 0.000

Z-score 0.68

OE 0.82 (0.53–1.30)

Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?

0.61Z-score

OE missense 0.87 (0.76–0.99)

153 obs / 175.9 exp

Tolerant

Mild missense constraint

Observed / Expected Ratios?

LoF OE?0.82 (0.53–1.30)

0≤0.351.4

Missense OE?0.87 (0.76–0.99)

0≤0.61.4

Synonymous OE?0.92

0≤1.21.6

LoF obs/exp: 13 / 15.9Missense obs/exp: 153 / 175.9Syn Z: 0.50

Background carrier burden — how many people carry a rare variant somewhere in IL20RB?

gnomAD v4 · ~731k individuals · PASS only

Rare means allele frequency under

Rare missense

1 in 180

372 rare PASS variants

Rare truncating (LoF)

1 in 2,900

52 rare PASS variants

Rare synonymous (reference)

1 in 400

167 rare PASS variants

Truncating variants are far rarer here than missense — that gap, in human units, is what constraint means for IL20RB. A background rate for each class, not the frequency of any particular variant; thin-coverage exons undercount.

By genetic ancestry · 9 gnomAD groups · rare = under 0.1% in that group

Group	People	Missense	Truncating
European (non-Finnish)	~556k	1 in 280	1 in 3,300
South Asian	~43k	1 in 140	1 in 5,300
Remaining (unassigned)	~30k	1 in 150	1 in 1,200
European (Finnish)	~27k	1 in 920	none seen
Admixed American	~22k	1 in 190	1 in 1,400
African / African American	~21k	1 in 160	1 in 3,000
East Asian	~20k	1 in 240	1 in 2,000
Ashkenazi Jewish	~13k	1 in 1,300	≈ 1 in 13,000
Middle Eastern	~2,884	1 in 320	≈ 1 in 2,900

Each group is summed over the variants that are rare in that group. Grey ≈ figures rest on fewer than five expected carriers — too few to distinguish groups. Differences mostly reflect how many people were sampled and how much variation each ancestry carries, not disease risk.

Exome coverage (gnomAD): 5 of 7 coding exons well covered in gnomAD exomes; exons 1, 7 marginal. Genomes: all 7.? see exons ↓