IL17B

Chr 5

interleukin 17B

Also known as: IL-17B, IL-20, NIRF, ZCYTO7

NCBI Gene: 27190ENSG00000127743UniProt: Q9UHF5

The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. Alternative splicing results in multiple splice variants. [provided by RefSeq, Dec 2015]

58
ClinVar variants
11
Pathogenic / LP
0.03
pLI score
0
Active trials
Clinical Summary— IL17B
⚡
Population Constraint (gnomAD)
Low constraint (pLI 0.03) — loss-of-function variants are relatively tolerated in the population.
📋
ClinVar Variants
11 Pathogenic / Likely Pathogenic· 41 VUS of 58 total submissions

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?LOEUF (Loss-of-function Observed/Expected Upper bound Fraction) is the upper bound of the 90% CI for LoF OE — the preferred gnomAD v4 metric. Lower = more intolerant to LoF. LOEUF < 0.35 = highly constrained.
1.24LOEUF
pLI 0.034
Z-score 1.19
OE 0.48 (0.22–1.24)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?Missense Z-score: standard deviations fewer missense variants observed vs. expected. Z > 3.09 (p < 0.001) = gene does not tolerate missense variation. OE missense < 0.6 is also considered constrained.
0.52Z-score
OE missense 0.87 (0.74–1.02)
108 obs / 124.5 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?Shaded band = 90% confidence interval. Vertical tick = point estimate. Grey threshold line = gnomAD constraint cutoff for that variant class.
LoF OE?Ratio of observed to expected LoF variants. Upper CI bound (LOEUF) ≤ 0.35 = strong LoF constraint signal.0.48 (0.22–1.24)
0≤0.351.4
Missense OE?Ratio of observed to expected missense variants. OE ≤ 0.6 = fewer missense variants than expected by chance.0.87 (0.74–1.02)
0≤0.61.4
Synonymous OE?Control metric — synonymous variants are largely neutral and expected near OE = 1.0. Significant deviation may indicate annotation issues.0.91
0≤1.21.6
LoF obs/exp: 3 / 6.2Missense obs/exp: 108 / 124.5Syn Z: 0.46

ClinVar Variant Classifications

58 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic11
VUS41
Likely Benign4
Benign2
11
Pathogenic
41
VUS
4
Likely Benign
2
Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
0
0
11
0
11
Likely Pathogenic
0
0
0
0
0
VUS
0
38
3
0
41
Likely Benign
0
1
1
2
4
Benign
0
0
1
1
2
Total03916358

LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

IL17B · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
INTERLEUKIN 17B; IL17B
MIM #604627 · *
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
The IL-17 Family of Cytokines in Psoriasis: IL-17A and Beyond.
Brembilla NC et al.·Front Immunol
2018Review
IL-17 in the immunopathogenesis of spondyloarthritis.
Taams LS et al.·Nat Rev Rheumatol
2018Review
IL-17 inhibitors for psoriasis.
Paek SY et al.·Semin Cutan Med Surg
2018Review
Endometrial senescence is mediated by interleukin 17 receptor B signaling.
Kawamura K et al.·Cell Commun Signal
2024
Spatial profiling reveals tissue-specific neuro-immune interactions in gastroenteropancreatic neuroendocrine tumors.
Duan S et al.·J Pathol
2024
Therapy of autoimmune inflammation in sporadic amyotrophic lateral sclerosis: Dimethyl fumarate and H-151 downregulate inflammatory cytokines in the cGAS-STING pathway.
Zamiri K et al.·FASEB J
2023
The Emerging Role of the IL-17B/IL-17RB Pathway in Cancer.
Bastid J et al.·Front Immunol
2020Review
Unveiling the role of ACTL6A in uveal melanoma metastasis and immune microenvironment.
Weiqin L et al.·Int Immunopharmacol
2025
Role of interleukin-17F in asthma.
Kawaguchi M et al.·Inflamm Allergy Drug Targets
2009Review
Variants in SKP1, PROB1, and IL17B genes at keratoconus 5q31.1-q35.3 susceptibility locus identified by whole-exome sequencing.
Karolak JA et al.·Eur J Hum Genet
2017
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools