IL13
Chr 5ADinterleukin 13
Also known as: IL-13, P600
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]
Primary Disease Associations & Inheritance
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
IL13 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
A Phase III Study to Assess the Efficacy and Safety of PG-011 Nasal Spray in Adults With Moderate to Severe Seasonal Allergic Rhinitis
NOT YET RECRUITINGHigh Definition Medicine for Solid Tumors Oncology
RECRUITINGMulti-Strain Probiotics Supplementation With Standard Care in Mild to Moderate Ulcerative Colitis
RECRUITINGEfficacy and Safety of Stapokibart in Non-Allergic Rhinitis With Eosinophilia Syndrome
NOT YET RECRUITINGHuman Milk Oligosaccharides (HMOs) and Gut Microbiota, Immune System in Antarctica
ENROLLING BY INVITATIONBiomarkers in Systemic Histiocytosis
NOT YET RECRUITINGGenetically Modified T-cells in Treating Patients With Recurrent or Refractory Malignant Glioma
ACTIVE NOT RECRUITINGBrain Tumor-Specific Immune Cells (IL13Ralpha2-CAR T Cells) for the Treatment of Leptomeningeal Glioblastoma, Ependymoma, or Medulloblastoma
ACTIVE NOT RECRUITINGSKIN Disease Profiling by an Exploratory, pRospective, Biomarker Study in dermatoloGY Practice (SKINERGY)
RECRUITINGDietary Intervention on Atopy
RECRUITINGEfficacy of Montelukast on STEMl Patients
RECRUITINGGenetic Association With Various Severities, Phenotypes and Endotypes of Asthma.
RECRUITINGExternal Resources
Links to major genomics databases and tools