IGLV3-27

Chr 22

immunoglobulin lambda variable 3-27

Also known as: IGLV327, V2-19

NCBI Gene: 28791ENSG00000211658UniProt: P01718

Predicted to enable antigen binding activity. Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]

35
ClinVar variants
21
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— IGLV3-27
📋
ClinVar Variants
21 Pathogenic / Likely Pathogenic· 12 VUS of 35 total submissions

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

35 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic19
Likely Pathogenic2
VUS12
Likely Benign1
Benign1
19
Pathogenic
2
Likely Pathogenic
12
VUS
1
Likely Benign
1
Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
————19
Likely Pathogenic
————2
VUS
————12
Likely Benign
————1
Benign
————1
Total—35

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

IGLV3-27 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
Clinical Literature
Landmark / reviewRecent case evidence

No publications found for IGLV3-27

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools