IGLV3-21

Chr 22

immunoglobulin lambda variable 3-21

Also known as: IGLV321, V2-14

NCBI Gene: 28796ENSG00000211662UniProt: P80748

Predicted to enable antigen binding activity. Predicted to be involved in immune response. Located in blood microparticle and extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

46
ClinVar variants
25
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— IGLV3-21
📋
ClinVar Variants
25 Pathogenic / Likely Pathogenic· 18 VUS of 46 total submissions

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

46 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic23
Likely Pathogenic2
VUS18
Likely Benign1
Benign1
Conflicting1
23
Pathogenic
2
Likely Pathogenic
18
VUS
1
Likely Benign
1
Benign
1
Conflicting

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
————23
Likely Pathogenic
————2
VUS
————18
Likely Benign
————1
Benign
————1
Conflicting
—1
Total—46

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

IGLV3-21 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
Mutation-specific CAR T cells as precision therapy for IGLV3-21(R110) expressing high-risk chronic lymphocytic leukemia.
Märkl F et al.·Nat Commun
2024
IGLV3-21R110 identifies an aggressive biological subtype of chronic lymphocytic leukemia with intermediate epigenetics.
Nadeu F et al.·Blood
2021
IGLV3-21*01 is an inherited risk factor for CLL through the acquisition of a single-point mutation enabling autonomous BCR signaling.
Maity PC et al.·Proc Natl Acad Sci U S A
2020
Adenoviral Inciting Antigen and Somatic Hypermutation in VITT.
Wang JJ et al.·N Engl J Med
2026
THE IGLV3-21 LIGHT CHAIN ANALYSIS IN CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS.
Abramenko IV et al.·Probl Radiac Med Radiobiol
2025Cohort
Novel skewed usage of B-cell receptors in COVID-19 patients with various clinical presentations.
Ma J et al.·Immunol Lett
2022Cohort
Higher-order immunoglobulin repertoire restrictions in CLL: the illustrative case of stereotyped subsets 2 and 169.
Gemenetzi K et al.·Blood
2021
Analysis of the complete lambda light chain germline usage in patients with AL amyloidosis and dominant heart or kidney involvement.
Berghaus N et al.·PLoS One
2022Cohort
Immunoglobulin light chain mutational status refines IGHV prognostic value in identifying chronic lymphocytic leukemia patients with early treatment requirement.
Nabki J et al.·Leukemia
2025Cohort
Molecular and clinical features of chronic lymphocytic leukaemia with stereotyped B cell receptors: results from an Italian multicentre study.
Bomben R et al.·Br J Haematol
2009
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools