IGLV3-12

Chr 22

immunoglobulin lambda variable 3-12

Also known as: IGLV312, V2-8

NCBI Gene: 28802ENSG00000211667UniProt: A0A075B6K2

Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]

46
ClinVar variants
25
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— IGLV3-12
📋
ClinVar Variants
25 Pathogenic / Likely Pathogenic· 18 VUS of 46 total submissions

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

46 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic23
Likely Pathogenic2
VUS18
Likely Benign1
Benign1
Conflicting1
23
Pathogenic
2
Likely Pathogenic
18
VUS
1
Likely Benign
1
Benign
1
Conflicting

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
————23
Likely Pathogenic
————2
VUS
————18
Likely Benign
————1
Benign
————1
Conflicting
—1
Total—46

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

IGLV3-12 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
Clinical Literature
Landmark / reviewRecent case evidence

No publications found for IGLV3-12

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools