IGDCC4

Chr 15

immunoglobulin superfamily DCC subclass member 4

Also known as: DDM36, NOPE

NCBI Gene: 57722 ENSG00000103742 UniProt: Q8TDY8

Predicted to be involved in cell-cell adhesion. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Research

Predicted to be involved in cell-cell adhesion. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

0.55

LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD

Moderate LoF intolerance

LoF Constraint?

0.55LOEUF

pLI 0.000

Z-score 4.12

OE 0.37 (0.26–0.55)

Moderately constrained

More LoF-intolerant than ~75% of genes

Missense Constraint?

1.73Z-score

OE missense 0.82 (0.76–0.88)

588 obs / 718.8 exp

Tolerant

Mild missense constraint

Observed / Expected Ratios?

LoF OE?0.37 (0.26–0.55)

0≤0.351.4

Missense OE?0.82 (0.76–0.88)

0≤0.61.4

Synonymous OE?0.96

0≤1.21.6

LoF obs/exp: 19 / 50.7Missense obs/exp: 588 / 718.8Syn Z: 0.62

Background carrier burden — how many people carry a rare variant somewhere in IGDCC4?

gnomAD v4 · ~731k individuals · PASS only

Rare means allele frequency under

Rare missense

1 in 35

1,608 rare PASS variants

Rare truncating (LoF)

1 in 690

211 rare PASS variants

Rare synonymous (reference)

1 in 56

747 rare PASS variants

Truncating variants are far rarer here than missense — that gap, in human units, is what constraint means for IGDCC4. A background rate for each class, not the frequency of any particular variant; thin-coverage exons undercount.

By genetic ancestry · 9 gnomAD groups · rare = under 0.1% in that group

Group	People	Missense	Truncating
European (non-Finnish)	~556k	1 in 50	1 in 840
South Asian	~43k	1 in 27	1 in 470
Remaining (unassigned)	~30k	1 in 26	1 in 510
European (Finnish)	~27k	1 in 100	1 in 560
Admixed American	~22k	1 in 28	1 in 360
African / African American	~21k	1 in 36	1 in 610
East Asian	~20k	1 in 30	1 in 300
Ashkenazi Jewish	~13k	1 in 120	1 in 880
Middle Eastern	~2,884	1 in 25	≈ 1 in 1,400

Each group is summed over the variants that are rare in that group. Grey ≈ figures rest on fewer than five expected carriers — too few to distinguish groups. Differences mostly reflect how many people were sampled and how much variation each ancestry carries, not disease risk.

Exome coverage (gnomAD): 18 of 20 coding exons well covered in gnomAD exomes; exons 1, 7 marginal. Genomes: 19 of 20 (exon 1 below).? see exons ↓