IFT25
Chr 1intraflagellar transport 25
Also known as: C1orf41, CFAP232, FAP232, HSPB11, HSPCO34, PP25
IFT25 encodes a component of intraciliary transport complex B that is required for sonic hedgehog signaling and mediates transport of signaling molecules within cilia. Mutations cause autosomal recessive ciliopathy with kidney developmental abnormalities and male infertility due to defective sperm flagella formation. The gene shows tolerance to loss-of-function variants, consistent with recessive inheritance patterns.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
IFT25 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools