IFIT1B

Chr 10

interferon induced protein with tetratricopeptide repeats 1B

ENSG00000204010UniProt: Q5T764

IFIT1B is likely non-functional, lacking the critical antiviral role of IFIT1. Unlike IFIT1, which is essential in the innate immune response as part of an interferon-dependent multiprotein complex, IFIT1B does not prevent the translation of viral RNAs that lack host-specific 2'-O-methylation at their 5' cap. Consequently, it probably cannot inhibit their translation by competing with the host translation machinery

ResearchGenerating clinical summary…
0
Active trials
0
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.91
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

ncbi: Error: NCBI fetch failed: 429 https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.91LOEUF
pLI 0.000
Z-score -0.64
OE 1.33 (0.69–1.91)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.24Z-score
OE missense 1.04 (0.94–1.16)
254 obs / 243.7 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?1.33 (0.69–1.91)
0≤0.351.4
Missense OE?1.04 (0.94–1.16)
0≤0.61.4
Synonymous OE?0.98
0≤1.21.6
LoF obs/exp: 6 / 4.5Missense obs/exp: 254 / 243.7Syn Z: 0.17

ClinVar

No ClinVar data available.

Protein Context — Lollipop Plot

IFIT1B · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients