IFI35

Chr 17

interferon induced protein 35

Also known as: IFP35

NCBI Gene: 3430ENSG00000068079UniProt: P80217

Enables identical protein binding activity. Involved in several processes, including macrophage activation involved in immune response; negative regulation of non-canonical NF-kappaB signal transduction; and positive regulation of defense response. Located in several cellular components, including cytosol; extracellular space; and nuclear lumen. [provided by Alliance of Genome Resources, Jul 2025]

0
Active trials
6
Pathogenic / LP
60
ClinVar variants
3
Pubs (1 yr)
-0.2
Missense Z
1.36
LOEUF
Clinical Summary— IFI35
⚡
Population Constraint (gnomAD)
Low constraint (pLI 0.00) — loss-of-function variants are relatively tolerated in the population.
📋
ClinVar Variants
6 Pathogenic / Likely Pathogenic· 49 VUS of 60 total submissions

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?LOEUF (Loss-of-function Observed/Expected Upper bound Fraction) is the upper bound of the 90% CI for LoF OE — the preferred gnomAD v4 metric. Lower = more intolerant to LoF. LOEUF < 0.35 = highly constrained.
1.36LOEUF
pLI 0.000
Z-score 0.60
OE 0.82 (0.52–1.36)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?Missense Z-score: standard deviations fewer missense variants observed vs. expected. Z > 3.09 (p < 0.001) = gene does not tolerate missense variation. OE missense < 0.6 is also considered constrained.
-0.25Z-score
OE missense 1.05 (0.93–1.20)
173 obs / 164.2 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?Shaded band = 90% confidence interval. Vertical tick = point estimate. Grey threshold line = gnomAD constraint cutoff for that variant class.
LoF OE?Ratio of observed to expected LoF variants. Upper CI bound (LOEUF) ≤ 0.35 = strong LoF constraint signal.0.82 (0.52–1.36)
0≤0.351.4
Missense OE?Ratio of observed to expected missense variants. OE ≤ 0.6 = fewer missense variants than expected by chance.1.05 (0.93–1.20)
0≤0.61.4
Synonymous OE?Control metric — synonymous variants are largely neutral and expected near OE = 1.0. Significant deviation may indicate annotation issues.0.96
0≤1.21.6
LoF obs/exp: 11 / 13.4Missense obs/exp: 173 / 164.2Syn Z: 0.28

ClinVar Variant Classifications

60 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic6
VUS49
Likely Benign5
6
Pathogenic
49
VUS
5
Likely Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
0
0
6
0
6
Likely Pathogenic
0
0
0
0
0
VUS
1
46
2
0
49
Likely Benign
0
5
0
0
5
Benign
0
0
0
0
0
Total1518060

LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

IFI35 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
Dysregulated immune and metabolic pathways are associated with poor survival in adult acute myeloid leukemia with CEBPA bZIP in-frame mutations.
Tien FM et al.·Blood Cancer J
2024
IFI35 as a biomolecular marker of neuroinflammation and treatment response in multiple sclerosis.
De Masi R et al.·Life Sci
2020
Mapping the Tumor Microenvironment in TNBC and Deep Exploration for M1 Macrophages-Associated Prognostic Genes.
Xu B et al.·Front Immunol
2022
circLRCH3-FUS interaction stabilizes IFI35 mRNA, inhibiting autophagy and aggravating podocyte pyroptosis in lupus nephritis.
Zhang L et al.·Int Immunopharmacol
2025
Screening of key genes related to the prognosis of mouse sepsis.
Chen M et al.·Biosci Rep
2020Functional
Interpretable machine learning identifies paediatric Systemic Lupus Erythematosus subtypes based on gene expression data.
Yones SA et al.·Sci Rep
2022
Clinical Values of the Identified Hub Genes in Systemic Lupus Erythematosus.
Xiao L et al.·Front Immunol
2022
IFI35, mir-99a and HCV genotype to predict sustained virological response to pegylated-interferon plus ribavirin in chronic hepatitis C.
Estrabaud E et al.·PLoS One
2015
Contribution of Rare Genetic Variation to Disease Susceptibility in a Large Scandinavian Myositis Cohort.
Bianchi M et al.·Arthritis Rheumatol
2022Cohort
A 2-Dose AERAS-402 Regimen Boosts CD8(+) Polyfunctionality in HIV-Negative, BCG-Vaccinated Recipients.
Sivakumaran D et al.·Front Immunol
2021Clinical trial
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Top 5 resultsSearch Europe PMC ↗
Full-Text Mentions
NLP-detected gene mentions in article bodies · via PubTator3
PubTator3
IFI35 Promotes Renal Cancer Progression by Inhibiting pSTAT1/pSTAT6-Dependent Autophagy
Chai D et al.·Cancers (Basel)
2022
IFI35 is involved in the regulation of the radiosensitivity of colorectal cancer cells
Hu Y et al.·Cancer Cell Int
2021
Characterization of chicken IFI35 and its antiviral activity against Newcastle disease virus
Jia YQ et al.·J Vet Med Sci
2022
GANAB as a Novel Biomarker in Multiple Sclerosis: Correlation with Neuroinflammation and IFI35
De Masi R et al.·Pharmaceuticals (Basel)
2021
Tumor-secreted IFI35 promotes proliferation and cytotoxic activity of CD8+ T cells through PI3K/AKT/mTOR signaling pathway in colorectal cancer
Li P et al.·J Biomed Sci
2023
Interferon Inducer IFI35 regulates RIG-I-mediated innate antiviral response through mutual antagonism with Influenza protein NS1.
Yang H et al.·J Virol
2021
The Identification Distinct Antiviral Factors Regulated Influenza Pandemic H1N1 Infection
Wang B et al.·Int J Microbiol
2024
Top 7 full-text resultsSearch PubTator3 ↗

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients