IDS
Chr XXLRiduronate 2-sulfatase
Also known as: ID2S, MPS2, SIDS
The protein functions as a lysosomal enzyme that degrades heparan sulfate and dermatan sulfate through its sulfatase activity. Mutations cause mucopolysaccharidosis type II (Hunter syndrome), an X-linked recessive lysosomal storage disorder. Loss of enzyme function leads to accumulation of these glycosaminoglycans in lysosomes, resulting in the progressive multisystem manifestations characteristic of Hunter syndrome.
Definitive — sufficient evidence for diagnostic panels
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly LoF-intolerant (top ~10% of genes)
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
IDS · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
A Study to Learn About the Study Medicine PF-07934040 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Genetic Mutation.
RECRUITINGA Prospective Registry for Patients at High-Risk for Pancreatic Cancer
RECRUITINGPrecision Medicine in the Treatment of Epilepsy
RECRUITINGTesting the Addition of Ipatasertib to the Usual Chemotherapy Treatment (Paclitaxel and Carboplatin) for Stage III or IV Epithelial Ovarian Cancer
ACTIVE NOT RECRUITINGA Study to Evaluate the Efficacy and Safety of Factor IX Gene Therapy With PF-06838435 in Adult Males With Moderately Severe to Severe Hemophilia B
ACTIVE NOT RECRUITINGAn Extension Study of the Long-Term Safety, Tolerability, and Efficacy of Tividenofusp Alfa (DNL310) in Participants With Mucopolysaccharidosis Type II (MPS II) From Study DNLI-E-0002 or Study DNLI-E-0007
ENROLLING BY INVITATIONGene Therapy With Modified Autologous Hematopoietic Stem Cells for Patients With Mucopolysaccharidosis Type II
ACTIVE NOT RECRUITINGLong Term Follow-up (LTFU) of Subjects Who Received SB-318, SB-913, or SB-FIX
ACTIVE NOT RECRUITINGCAMPSIITE™ RGX-121 Gene Therapy in Subjects With MPS II (Hunter Syndrome)
ACTIVE NOT RECRUITINGMicrodevice In Ovarian, Fallopian Tube, And Peritoneal Cancer
RECRUITINGTopical Probiotic Sinus Irrigations for Treating Chronic Sinusitis
RECRUITINGStudy to Evaluate the Efficacy and Safety of PF-07055480 / Giroctocogene Fitelparvovec Gene Therapy in Moderately Severe to Severe Hemophilia A Adults
ACTIVE NOT RECRUITINGExternal Resources
Links to major genomics databases and tools