ID4

Chr 6

inhibitor of DNA binding 4

Also known as: IDB4, bHLHb27

This gene encodes a member of the inhibitor of DNA binding (ID) protein family. The encoded protein lacks DNA binding ability, and instead regulates gene expression through binding to and inhibiting basic helix-loop-helix transcription factors. This protein has been implicated in the regulation of diverse cellular processes that play a role in development and tumorigenesis. [provided by RefSeq, Aug 2017]

ResearchGenerating clinical summary…
0
Active trials
49
Pubs (1 yr)
P/LP submissions
P/LP missense
1.83
LOEUF
LOF
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.83LOEUF
pLI 0.031
Z-score 0.23
OE 0.84 (0.321.83)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.86Z-score
OE missense 1.31 (1.091.59)
77 obs / 58.6 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.84 (0.321.83)
00.351.4
Missense OE?1.31 (1.091.59)
00.61.4
Synonymous OE?2.00
01.21.6
LoF obs/exp: 2 / 2.4Missense obs/exp: 77 / 58.6Syn Z: -4.16

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

ID4 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →