HTR1F

Chr 3

5-hydroxytryptamine receptor 1F

Also known as: 5-HT-1F, 5-HT1F, 5HT6, HTR1EL, MR77

NCBI Gene: 3355ENSG00000179097UniProt: P30939

Enables Gi/o-coupled serotonin receptor activity and serotonin binding activity. Involved in adenylate cyclase-inhibiting serotonin receptor signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…
0
Active trials
8
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.10
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.10LOEUF
pLI 0.005
Z-score 1.37
OE 0.52 (0.27–1.10)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
1.03Z-score
OE missense 0.79 (0.69–0.91)
150 obs / 189.8 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.52 (0.27–1.10)
0≤0.351.4
Missense OE?0.79 (0.69–0.91)
0≤0.61.4
Synonymous OE?1.26
0≤1.21.6
LoF obs/exp: 5 / 9.6Missense obs/exp: 150 / 189.8Syn Z: -1.70

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

HTR1F · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients