HTR1E

Chr 6

5-hydroxytryptamine receptor 1E

Also known as: 5-HT1E

NCBI Gene: 3354 ENSG00000168830 UniProt: P28566

HTR1E encodes a G-protein coupled receptor for serotonin that inhibits adenylate cyclase activity and mediates inhibitory neurotransmission in the brain. Mutations cause autosomal recessive intellectual disability with onset in early childhood. The gene shows moderate constraint against loss-of-function variants.

ResearchSummary from RefSeq, UniProt

Enables Gi/o-coupled serotonin receptor activity and serotonin binding activity. Involved in adenylate cyclase-inhibiting serotonin receptor signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant

This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

0.78

LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (1)

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