HTN1

Chr 4

histatin 1

Also known as: HIS1, Hst1

NCBI Gene: 3346 ENSG00000126550 UniProt: P15515

The HTN1 gene encodes histatin 1, a small histidine-rich cationic protein secreted in saliva that functions as an antimicrobial peptide and promotes wound healing in oral and non-oral mucosa. HTN1 is tolerant to loss-of-function variants (LOEUF 1.74), and no pediatric neurological diseases have been definitively associated with HTN1 mutations. This gene primarily relates to oral health and innate immunity rather than neurological function.

ResearchSummary from RefSeq, UniProt

This gene encodes a member of the histatin family of small, histidine-rich, cationic proteins. They function as antimicrobial peptides and are important components of the innate immune system. Histatins are found in saliva and exhibit antibacterial, antifungal activities and function in wound healing. [provided by RefSeq, Aug 2014]

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

1.74

LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (1)