HSFY1
Chr Yheat shock transcription factor Y-linked 1
Also known as: HSF2L, HSFY
This gene encodes a heat shock factor family transcriptional activator that regulates heat shock protein expression and is located on the Y chromosome in a region associated with male infertility. Deletions involving HSFY1 are linked to azoospermia and male infertility. The gene follows Y-linked inheritance, passing from father to son.
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
87 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | — | — | — | — | 62 |
Likely Pathogenic | — | — | — | — | 2 |
VUS | — | — | — | — | 10 |
Likely Benign | — | — | — | — | 10 |
Benign | — | — | — | — | 2 |
Conflicting | — | 1 | |||
| Total | — | 87 | |||
Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
HSFY1 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →No open access results found
External Resources
Links to major genomics databases and tools