HS3ST4
Chr 16heparan sulfate-glucosamine 3-sulfotransferase 4
Also known as: 3-OST-4, 30ST4, 3OST4, h3-OST-4
The HS3ST4 protein is a sulfotransferase enzyme that catalyzes the transfer of sulfate groups to specific glucosamine residues in heparan sulfate, modifying this important cell surface glycosaminoglycan. This gene is highly constrained against loss-of-function variants, but disease-causing mutations and associated clinical phenotypes have not yet been established in humans. Inheritance pattern remains to be determined as pathogenic variants have not been reported.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
More LoF-intolerant than ~75% of genes
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
HS3ST4 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →No open access results found
External Resources
Links to major genomics databases and tools