HPGDS

Chr 4

hematopoietic prostaglandin D synthase

Also known as: GSTS, GSTS1, GSTS1-1, PGD2, PGDS

NCBI Gene: 27306ENSG00000163106UniProt: O60760

Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes. [provided by RefSeq, Jul 2008]

ResearchGenerating clinical summary…
0
Active trials
33
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.63
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.63LOEUF
pLI 0.000
Z-score 0.14
OE 0.95 (0.57–1.63)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-1.03Z-score
OE missense 1.28 (1.11–1.48)
135 obs / 105.4 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.95 (0.57–1.63)
0≤0.351.4
Missense OE?1.28 (1.11–1.48)
0≤0.61.4
Synonymous OE?1.09
0≤1.21.6
LoF obs/exp: 9 / 9.5Missense obs/exp: 135 / 105.4Syn Z: -0.43

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

HPGDS · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients