HOTTIP

Chr 7

HOXA distal transcript antisense RNA

Also known as: HOXA-AS6, HOXA13-AS1, NCRNA00213

NCBI Gene: 100316868ENSG00000243766

This gene produces a long RNA in antisense to the HOXA gene cluster. This transcript may regulate expression of HOXA genes in cis. This gene is upregulated in tumors and is implicated in the promotion of cell proliferation. [provided by RefSeq, Dec 2017]

33
ClinVar variants
30
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— HOTTIP
📋
ClinVar Variants
30 Pathogenic / Likely Pathogenic· 3 VUS of 33 total submissions

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

33 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic27
Likely Pathogenic3
VUS3
27
Pathogenic
3
Likely Pathogenic
3
VUS

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
————27
Likely Pathogenic
————3
VUS
————3
Likely Benign
————0
Benign
————0
Total—33

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

HOTTIP · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
Diagnostic efficacy of an extracellular vesicle-derived lncRNA-based liquid biopsy signature for the early detection of early-onset gastric cancer.
Guo X et al.·Gut
2025
HOXA9 Regulome and Pharmacological Interventions in Leukemia.
Aryal S et al.·Adv Exp Med Biol
2024Review
The prognostic value of long noncoding RNA HOTTIP on clinical outcomes in breast cancer.
Yang Y et al.·Oncotarget
2017Review
Long non‑coding RNA HOTTIP promotes hepatocellular carcinoma tumorigenesis and development: A comprehensive investigation based on bioinformatics, qRT‑PCR and meta‑analysis of 393 cases.
Zhang Y et al.·Int J Oncol
2017Meta-analysis
-Long noncoding RNA HOTTIP as a novel predictor of lymph node metastasis and survival in human cancer: a systematic review and meta-analysis.
Chen Z et al.·Oncotarget
2017Meta-analysis
Long Noncoding RNAs as Therapeutic Targets.
Pierce JB et al.·Adv Exp Med Biol
2022Review
LncRNA HOTTIP modulated by Hedgehog signaling drives colorectal cancer progression by promoting HUWE1-mediated ubiquitin‒proteasome degradation of p53.
Wang H et al.·Cell Death Dis
2025
The HOTTIP (HOXA transcript at the distal tip) lncRNA: Review of oncogenic roles in human.
Ghafouri-Fard S et al.·Biomed Pharmacother
2020Review
The Diverse Roles of Long Non-Coding RNA HOTTIP in Breast and Gynecological Cancer Progression.
Dari MAG et al.·Curr Mol Med
2025Review
HOTTIP suppresses ferroptosis via mediating DGCR8/miR‑214‑3p/GPX4 regulatory axis in osteosarcoma.
Ding SC et al.·Oncol Rep
2025
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Downregulation of lncRNA HOTTIP alleviates neuropathic pain and inflammation in chronic constriction injury rats by targeting miR-216a-5p.
Zan G et al.·Korean J Pain
2026🔓 Open Access
Lack of association between HOTTIP rs3807598 C>G and venous malformation risk in Chinese children.
Xie S et al.·Transl Pediatr
2025🔓 Open Access
Evaluation of Genetic Polymorphisms of HOTTIP (rs5883064, rs1859168, rs2067087) in Patients with Non-Hodgkin Lymphoma and Comparison with Healthy Subjects.
Sadraei M et al.·Asian Pac J Cancer Prev
2025🔓 Open AccessCohort
Upregulation of HOTTIP and Its Potential Role in Monitoring Exercise Adaptation.
Mołoń A et al.·Int J Mol Sci
2025🔓 Open Access
The impact of long non-coding RNA HOTTIP genetic variants on oral cancer progression and clinicopathological characteristics.
Chen PJ et al.·J Cancer
2025🔓 Open Access
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools