HNRNPCL1

Chr 1

heterogeneous nuclear ribonucleoprotein C like 1

Also known as: HNRPCL1

NCBI Gene: 343069 ENSG00000179172 UniProt: O60812

The protein enables identical protein binding activity and is predicted to function in ribonucleoprotein complexes within the nucleus, potentially involved in nucleosome assembly through neutralization of basic proteins. Currently, no established disease associations have been reported for mutations in this gene. The gene shows relatively low constraint to loss-of-function variation (pLI 0.37, LOEUF 1.77), suggesting tolerance to such variants in the general population.

ResearchSummary from RefSeq, UniProt

Enables identical protein binding activity. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant

This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.

Active trials

Pubs (1 yr)

—

P/LP submissions

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P/LP missense

1.77

LOEUF

Mechanism· predicted

Some data sources returned errors (1)

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