HEMGN
Chr 9hemogen
Also known as: CT155, EDAG, EDAG-1, NDR
The protein regulates hematopoietic cell proliferation and differentiation, blocking megakaryocytic differentiation when overexpressed and potentially preventing apoptosis through NF-kB activation. The extremely low pLI score and elevated LOEUF indicate this gene is tolerant to loss-of-function variants, and no established human disease associations have been identified for HEMGN mutations.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
HEMGN · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
Safety and Efficacy Evaluation of β-globin Restored Autologous Hematopoietic Stem Cells in β-thalassemia Major Patients
RECRUITINGEvaluating Safety and Efficacy of Lentiviral-transduced CD34+ HSCs in Β-thalassaemia Patients.
RECRUITINGExternal Resources
Links to major genomics databases and tools