HCG22

Chr 6

HLA complex group 22

Also known as: PBMUCL2

NCBI Gene: 285834ENSG00000228789UniProt: E2RYF7

Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

8
ClinVar variants
6
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— HCG22
📋
ClinVar Variants
6 Pathogenic / Likely Pathogenic· 2 VUS of 8 total submissions

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

8 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic4
Likely Pathogenic2
VUS2
4
Pathogenic
2
Likely Pathogenic
2
VUS

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
————4
Likely Pathogenic
————2
VUS
————2
Likely Benign
————0
Benign
————0
Total—8

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

HCG22 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
Comprehensive bioinformatics analysis identifies lncRNA HCG22 as a migration inhibitor in esophageal squamous cell carcinoma.
Li X et al.·J Cell Biochem
2020
Identification of Potential Diagnostic Biomarkers and Drug Targets for Endometriosis from a Genetic Perspective: A Mendelian Randomization Study.
Wang W et al.·Gynecol Obstet Invest
2025
Multiomics Immune-Related lncRNA Analysis of Oral Squamous Cell Carcinoma and Its Correlation with Prognosis.
Liu Z et al.·Dis Markers
2022
Genome-Wide Analyses Reveal Gene Influence on HIV Disease Progression and HIV-1C Acquisition in Southern Africa.
Xie W et al.·AIDS Res Hum Retroviruses
2017
Construction and analysis of a lncRNA-miRNA-mRNA network based on competitive endogenous RNA reveal functional lncRNAs in oral cancer.
Yin J et al.·BMC Med Genomics
2020Functional
A genome-wide association study identifies 6p21 as novel risk locus for dilated cardiomyopathy.
Meder B et al.·Eur Heart J
2014
How Long Non-Coding RNAs and MicroRNAs Mediate the Endogenous RNA Network of Head and Neck Squamous Cell Carcinoma: a Comprehensive Analysis.
Zhao G et al.·Cell Physiol Biochem
2018
Transcriptomic analysis reveals key lncRNAs associated with ribosomal biogenesis and epidermis differentiation in head and neck squamous cell carcinoma.
Guo YZ et al.·J Zhejiang Univ Sci B
2018
Integrated analysis of a competing endogenous RNA network reveals key lncRNAs as potential prognostic biomarkers for human bladder cancer.
Zhu N et al.·Medicine (Baltimore)
2018
Characterization of mRNA Expression and Endogenous RNA Profiles in Bladder Cancer Based on The Cancer Genome Atlas (TCGA) Database.
Xu Z et al.·Med Sci Monit
2019
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools